Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy

Autores:  Florencia B. González • Antonella Pacini • Araceli Castro • Susana Lioi • Silvina R. Villar • Luciano D’Attilio • Rodolfo D. Leiva • Liliana Favaloro • Oscar A. Bottasso • Carlos A. Vigliano • Ana Rosa Pérez

Resumen: Chronic Chagasic Cardiomyopathy (CCC) has an infectious and inflammatory nature. Recent data also suggest an association with altered regulation of glucocorticoid (GC)-mediated circuits failing to control systemic inflammation. However, the involvement of glucocorticoid receptors (GR) and their isoforms have been unexplored.

Disponible en: Frontiers